Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range
نویسندگان
چکیده
منابع مشابه
Secreted frizzled-related proteins are required for Wnt/β-catenin signalling activation in the vertebrate optic cup.
Secreted frizzled-related proteins (Sfrps) are considered Wnt signalling antagonists but recent studies have shown that specific family members enhance Wnt diffusion and thus positively modulate Wnt signalling. Whether this is a general and physiological property of all Sfrps remains unexplored. It is equally unclear whether disruption of Sfrp expression interferes with developmental events med...
متن کاملSecreted frizzled related proteins: Implications in cancers.
The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years, aberrant ...
متن کاملBeyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease.
The secreted Frizzled-related proteins (SFRPs) are a family of soluble proteins that are structurally related to Frizzled (Fz) proteins, the serpentine receptors that mediate the extensively used cell-cell communication pathway involving Wnt signalling. Because of their homology with the Wnt-binding domain on the Fz receptors, SFRPs were immediately characterised as antagonists that bind to Wnt...
متن کاملFritz: a secreted frizzled-related protein that inhibits Wnt activity
Signaling molecules of the Wnt gene family are involved in the regulation of dorso-ventral, segmental and tissue polarity in Xenopus and Drosophila embryos. Members of the frizzled gene family, such as Drosophila frizzled-2 and rat frizzled-1, have been shown encode Wnt binding activity and to engage intracellular signal transduction molecules known to be part of the Wnt signaling pathway. Here...
متن کاملStructurally Related Receptors and Antagonists Compete for Secreted Wnt Ligands
tian and Moon, 1993) outside the organizer (Figure 1). Julia A. Yang-Snyder,* and Jeffrey R. Miller* Both specialists and nonspecialists examining these *Howard Hughes Medical Institute patterns of gene expression can appreciate Spemann’s and Department of Pharmacology image of interlocking fragments, and appreciate why †Molecular and Cellular Biology Program dissecting the workings of the gast...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Development
سال: 2009
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.032524